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Article

Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.

Archives of toxicology - 1 Sept 2016

Gómez-Lechón María José, Tolosa Laia

Abstract excerpt

Drug-induced liver injury (DILI) is a frequent cause of failure in both clinical and post-approval stages of drug development, and poses a key challenge to the pharmaceutical industry. Current animal models offer poor prediction of human DILI. Although several human cell-based models have been proposed for the detection of human DILI, human primary hepatocytes remain the gold standard for preclinical...

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PMID: 27325232
DOI: 10.1007/s00204-016-1756-1

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