Article

PD1+TIGIT+2B4+KLRG1+ cells might underlie T-cell dysfunction in patients treated with BCMA-directed CAR-T therapy

2023-01-31

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR-T) cell therapy has shown rapid, frequent and deep responses in patients with relapsed, refractory multiple myeloma (RRMM). However, relapse following CAR-T is frequently observed and the cause for resistance is not well defined. Among the potential mechanism of resistance, T cell intrinsic factors may be an important source of failure. Here, we used spect...

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Literature Corpus work: d05f3899-2646-5224-b411-ba78659f1d25
DOI: 10.21203/rs.3.rs-2518935/v1

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