Article

Acquired resistance to bispecific antibodies by genetic or epigenetic inactivation of the target in multiple myeloma

2023-06-14

Abstract excerpt

<title>Abstract</title> <p>Bispecific antibodies targeting CD3 on T cells and GPRC5D on plasma cells (talquetamab) demonstrated promising efficacy in multiple myeloma, but acquired resistance usually occurs within a few months. Using a single-nucleus multi-omic strategy in 3 patients with acquired talquetamab resistance, we identified two mechanisms of GPRC5D inactivation, by bi-allelic genetic inactivation, or b...

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Literature Corpus work: b2d4b287-6d06-5958-8040-75269a1797b9
DOI: 10.21203/rs.3.rs-2573797/v1

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