Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites

Abstract excerpt

Transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates. Unlike virtually every other eukaryote, which express identical rRNA from large tandem arrays of dozens to hundreds of identical rRNA genes in every cell, the genome of the human malaria parasite Plasmodium falciparum contains only a handful single-co...

Topics

Open a Topic to create a Post that cites this publication.

• Base Sequence
• Computational Drug Discovery Methods
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Malaria Research and Control
• Molecular Sequence Data
• Oligodeoxyribonucleotides
• Trypanosoma species research and implications

Identifiers and source

Literature Corpus work

d024fc98-7e0b-5f74-8208-1f39e14a0c19

DOI

10.1101/2024.09.02.610888