Biological proof of a hit-and-run tumour formation in oropharyngeal cancers

Abstract excerpt

<title>Abstract</title> <p>It has long been wondered if viruses cause cancer via a “hit-and-run” mechanism. We examined this in HPV-driven oropharyngeal cancer (OPC) using CRISPR to delete the viral oncogene, E7. Tumours regressed yet regrew over 3 months, despite the lack of E7, and had formed new mutations commonly found in HPV- OPC patient tumours. This is the first biological proof that HPV- OPCs can be forme...

Topics

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• Cell Transformation, Neoplastic
• CRISPR and Genetic Engineering
• Disease Progression
• Genomic Instability
• Mutation
• Neoplasms
• Oncogenes
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

cffda3bd-aa14-5b2f-ad60-5666855e9f16

DOI

10.21203/rs.3.rs-1991904/v1