A genomic approach to study down syndrome and cancer inverse comorbidity: untangling the chromosome 21

Abstract excerpt

Down syndrome (DS), one of the most common birth defects and the most widespread genetic cause of intellectual disabilities, is caused by extra genetic material on chromosome 21 (HSA21). The increased genomic dosage of trisomy 21 is thought to be responsible for the distinct DS phenotypes, including an increased risk of developing some types of childhood leukemia and germ cell tumors. Patients with DS, however,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Down syndrome and intellectual disability research
• Share to Genomic variations and chromosomal abnormalities
• Share to Prenatal Screening and Diagnostics