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Article

AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients.

The pharmacogenomics journal - 1 Oct 2021

Wajda Anna, Walczuk Ewa, Stypińska Barbara, Lach Jakub, Yermakovich Danat, Sivitskaya Larysa, Romanowska-Próchnicka Katarzyna, Wysocki Tomasz, Jarończyk Małgorzata, Paradowska-Gorycka Agnieszka

Abstract excerpt

Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX metabolism. In the present retrospective study, we analyzed genes expression of AHR genes battery associated with MTX metabolism in whole blood of RA patients with good and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34302046
DOI: 10.1038/s41397-021-00238-4
PMCID: PMC8455325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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