Article

Impaired arginine-induced insulin secretion in MODY2 patient with UGGT1R1526C variant

2022-03-02

Abstract excerpt

Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER). PSIPRED analysis showed that the arginine/proinsulin binding domain (A/PBD) in the C-terminal region of UGGT1 forms a disordered region, which is flexible and outside of the main protein structure. Arginine and proinsulin may easily access UGGT1. Using the SNP library, two variants, Q1518* and R1526C, were identified in this regi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfce628c-118f-50c0-b497-992e3b104a6f
DOI: 10.21203/rs.3.rs-1371648/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Impaired arginine-induced insulin secretion in MODY2 patient with UGGT1R1526C variantDOI 10.21203/rs.3.rs-1371648/v1Read

Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family.Semantic proximity Read

Comprehensive Computational Analysis Revealed Seven Novel Mutations in Human Insulin geneSemantic proximity Read

Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations.Semantic proximity Read

Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth.Semantic proximity Read

Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects.Semantic proximity Read

Role of Proinsulin Self-Association in Mutant <i>INS</i> gene-induced Diabetes of YouthSemantic proximity Read

Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.Semantic proximity Read

Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients.Semantic proximity Read