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Article

Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients.

International journal of molecular sciences - 31 Oct 2023

Cho Jaeyong, Horikawa Yukio, Oiwa Yuki, Hosomichi Kazuyoshi, Yabe Daisuke, Imai Takeshi

Abstract excerpt

We previously reported that glucokinase undergoes ubiquitination and subsequent degradation, a process mediated by cereblon, particularly in the presence of uridine diphosphate glucose (UDP-glucose). In this context, we hereby present evidence showcasing the resilience of variant glucokinase proteins of maturity-onset diabetes of the young type 2 (MODY2) against degradation and, concomitantly, their influence on...

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Identifiers

PMID: 37958824
DOI: 10.3390/ijms242115842
PMCID: PMC10649437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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