Article

Effect of the Proteasome Inhibitor, Bortezomib, on Histone Modifications in Human Leukemic Cell Lines

2026-06-12

Abstract excerpt

Histone-modifying enzymes and histone post-translational modifications (PTMs) play key roles in the organization (euchromatin versus heterochromatin) and function (active versus silenced genes) of chromatin. The abundance and activity of these enzymes, along with their associated histone PTMs, are often altered in cancer cells, leading to deregulated gene expression. The expression of the KMT2A-MLLT3 protein, resu...

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Literature Corpus work: cfb5d3b6-e145-5ccc-a076-b9e586f8f687
DOI: 10.20944/preprints202606.1025.v1

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