Article

Age-Dependent Effects of UV Exposure and Xeroderma Pigmentosum Group A on DNA Damage, Repair Mechanisms, Genomic Instability, Cancer Risk, and Neurological Disorders

2024-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Xeroderma pigmentosum, complementation group A (XPA), is a rare genetic disorder characterized by marked sensitivity to ultraviolet (UV) radiation, leading to increased risks of skin cancer, accelerated aging, and significant neurologic disorders. XPA prominently impacts DNA repair mechanisms, specifically nucleotide excision repair (NER), which is crucial for correcting UV-in...

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Literature Corpus work: cf7ac7a8-7f56-5dc6-aa96-10922224c3e6
DOI: 10.1101/2024.07.22.24310800

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