Bias in miRNA enrichment analysis related to gene functional annotations

Abstract excerpt

<h4>Background</h4> miRNA functional enrichment is a type of analysis that is used to predict which biological functions may be affected by a group of miRNAs or validate whether a list of dysregulated miRNAs are linked to a diseased state. The standard method for functional enrichment analysis uses the hypergeometric distribution to produce p-values, depicting the strength of the association between a group of mi...

Topics

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• Artificial Intelligence
• Computational Biology
• Gene Expression
• MicroRNAs
• Oligonucleotide Array Sequence Analysis
• Polymorphism, Single Nucleotide
• Real-Time Polymerase Chain Reaction
• Support Vector Machine

Identifiers and source

Literature Corpus work

cf63920e-192e-5d9b-8111-bd47f3ff07ab

DOI

10.1101/2021.08.16.456527