Article

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition

2022-05-04

Abstract excerpt

SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8 + T cell-mediated immunity by VOC. Here, we demonstrated that all SARS-CoV-2 VOCs possess the ability to suppress MHC I expression. We identified several viral genes th...

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Literature Corpus work: cf534cc6-de47-529b-b36e-e34d585393d9
DOI: 10.1101/2022.05.04.490614

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