Back to search

Article

DDX20 interlinking with SNRPE endows MYC-driven triple-negative breast cancer therapeutic vulnerability in a splicing-independent manner

2022-12-16

Abstract excerpt

<h4>Background: </h4> Aberrant splicing is a hallmark of cancer. For MYC-driven cancers, such as triple-negative breast cancer, hypersensitivity to spliceosome-targeted therapy is a novel anticancer strategy since it also triggers antitumorimmunity. Of the approximately 200 known spliceosomal genes, core spliceosomes are essential for cancer cell survival, yet the underlying mechanisms remain elusive. <h4>Methods...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cf418516-b4ce-5f11-aada-6ff3a2b443e1
DOI
10.21203/rs.3.rs-2375888/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DDX20 interlinking with SNRPE endows MYC-driven triple-negative breast cancer therapeutic vulnerability in a splicing-independent mannerDOI 10.21203/rs.3.rs-2375888/v1
SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulationSemantic proximity
Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancerSemantic proximity
Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma modelsSemantic proximity
The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cellsSemantic proximity
LncRNA Inhibits the Viability of Triple-Negative Breast Cancer (TNBC) by Targeting the miR-330-5p/BCL2L2 AxisSemantic proximity
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progressionSemantic proximity
A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiencySemantic proximity
Harnessing DNA Tetrahedral Nanoparticles: A Novel Strategy for Co- delivery of OTUD6B siRNA and DOX Against TNBC Growth and ProgressionSemantic proximity
Cancer-associated SNRPD3 mutation confers resistance to hypoxia, which is attenuated by DRP1 inhibition.Semantic proximity
Differential expression and function of SVIP in breast cancer cell lines and <i>in silico</i> analysis of its expression and prognostic potential in human breast cancerSemantic proximity
A novel RNA-binding activity of ECD contributes to U5 snRNP stability and pre-mRNA splicingSemantic proximity
NSMCE2, a Novel Super-Enhancer-Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast CancerSemantic proximity
Select a neighboring publication to make it the new centre.