Article

A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical model

2026-03-08

Abstract excerpt

<title>Abstract</title> <p>Interest in leveraging FDA approved "self-complementary" adeno-associated viral (scAAV) vectors for osteoarthritis treatment has been steadily rising. Due to the multi-faceted nature of osteoarthritis (an inflammatory/catabolic environment), we investigated the efficacy of a combined scAAV-based gene therapy approach to treating post-traumatic osteoarthritis (PTOA) in an equine preclini...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a039ae5b-f79b-5506-bd26-3bfc2297e293
DOI: 10.21203/rs.3.rs-8960268/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical modelDOI 10.21203/rs.3.rs-8960268/v1Read

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of OsteoarthritisSemantic proximity Read

Gene therapy approaches for equine osteoarthritisSemantic proximity Read

Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine ModelSemantic proximity Read

<i>Ex Vivo</i> Serotype-Specific Transduction of Equine Joint Tissue by Self-Complementary Adeno-Associated Viral VectorsSemantic proximity Read

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain MechanismsSemantic proximity Read

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytesSemantic proximity Read

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directionsSemantic proximity Read

Sequential intra-articular HCAd-NFκB-IL-1Ra delivery improves therapeutic efficacy in post-traumatic osteoarthritisSemantic proximity Read

Multi-Target Gene Therapy for Osteoarthritis: A Computational and Structural Analysis FrameworkSemantic proximity Read

Navigating the Hurdles of Intra-articular AAV Gene TherapySemantic proximity Read

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico ValidationSemantic proximity Read

New treatment for osteoarthritis: Gene therapySemantic proximity Read