Article

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis

2022-02-14

Abstract excerpt

Spinal muscular atrophy (SMA) is a congenital neuromuscular disease caused by the mutation or deletion of survival motor neuron 1 ( SMN1 ) gene. Although the primary cause of progressive muscle atrophy in SMA has classically been considered the degeneration of motor neurons, recent studies have indicated a skeletal muscle-specific pathological phenotype such as impaired mitochondrial function and enhanced cell d...

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Literature Corpus work: cee1fcbd-2613-5fcf-a70c-64db174c8d49
DOI: 10.1101/2022.02.13.480288

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