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Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics

23 Apr 2014

Abstract excerpt

While spinal muscular atrophy (SMA) is characterized by motor neuron degeneration, it is unclear whether and how much survival motor neuron (SMN) protein deficiency in muscle contributes to the pathophysiology of the disease. There is increasing evidence from patients and SMA model organisms that SMN deficiency causes intrinsic muscle defects. Here we investigated the role of SMN in muscle development using...

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PMID: 24760765
DOI: 10.1093/hmg/ddu189

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Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamicsPMID 24760765Read ↗

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