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Article

Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy Cells

15 Dec 2014

Abstract excerpt

Spinal muscular atrophy (SMA) is one of the most common inherited causes of pediatric mortality. SMA is caused by deletions or mutations in the survival of motor neuron 1 (SMN1) gene, which results in SMN protein deficiency. Humans have a centromeric copy of the survival of motor neuron gene, SMN2, which is nearly identical to SMN1. However, SMN2 cannot compensate for the loss of SMN1 because SMN2 has a...

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PMID: 25506695
DOI: 10.1371/journal.pone.0115205

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Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy CellsPMID 25506695Read ↗

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A Role for SMN Exon 7 Splicing in the Selective Vulnerability of Motor Neurons in Spinal Muscular AtrophySemantic proximity Read ↗

Htra2-β 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 ( SMN2 )Semantic proximity Read ↗

hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicingSemantic proximity Read ↗

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