Article

Genomic stress drives activation of interferon signaling and innate immune pathways during SMA Type II myoblasts differentiation

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of the SMN1 gene. The SMN protein is ubiquitously expressed and has several roles in the cell, including the regulation of RNA metabolism and genome stability. Although SMA is primarily considered a motor neuron disease, because of its ubiquitous expression, loss of SMN leads to systemic pathological consequences, includin...

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Literature Corpus work: 62257fe9-fde8-553b-a622-b6da8ca1931c
DOI: 10.64898/2025.12.23.696216

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