Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma.

doi:10.1053/j.gastro.2021.01.220

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Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma.

Gastroenterology - 1 May 2021

Golan Talia, O'Kane Grainne M, Denroche Robert E, Raitses-Gurevich Maria, Grant Robert C, Holter Spring, Wang Yifan, Zhang Amy, Jang Gun Ho, Stossel Chani, Atias Dikla, Halperin Sharon, Berger Raanan, Glick Yulia, Park J Patrick, Cuggia Adeline, Williamson Laura, Wong Hui-Li, Schaeffer David F, Renouf Daniel J, Borgida Ayelet, Dodd Anna, Wilson Julie M, Fischer Sandra E, Notta Faiyaz, Knox Jennifer J, Zogopoulos George, Gallinger Steven

Abstract excerpt

BACKGROUND AND AIMS: Homologous recombination deficiency (HRD) in pancreatic ductal adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in BRCA1, BRCA2, and PALB2. METHODS: We interrogated whole genome sequencing (WGS) data on 391 patients, including 49 carriers of pathogenic variants (PVs) in gBRCA and PALB2. HRD classifiers were applied to the dataset and included (1) the genomic...

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PMID: 33524400
DOI: 10.1053/j.gastro.2021.01.220

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