Article

Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition

2025-04-19

Abstract excerpt

<h4>ABSTRACT</h4> Subretinal fibrosis, a major cause of irreversible vision loss in neovascular age-related macular degeneration (nAMD), is driven by excessive deposition of extracellular matrix such as collagens. While proline metabolism is known to play a critical role in collagen biosynthesis and fibrosis, its involvement in subretinal fibrosis remains unclear. Here, we characterized the progression of fibrova...

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Literature Corpus work: ce0b6e82-0498-51b3-a424-f609dc93e204
DOI: 10.1101/2025.04.13.648057

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