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Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis

5 Apr 2022

Abstract excerpt

Abstract Background Macular subretinal fibrosis is the end-stage complication of neovascular age-related macular degeneration (nAMD). We previously developed a mouse model of two-stage laser-induced subretinal fibrosis that mimics closely the dynamic course of macular fibrosis in nAMD patients. This study was aimed to understand the molecular mechanism of subretinal fibrosis. Methods Subretinal fibrosis was...

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PMID: 35382832
DOI: 10.1186/s12974-022-02433-x

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