Article

Modifying Azithromycin to Mitigate Arrested Autophagy

2024-04-26

Abstract excerpt

<h4>Aims/hypothesis</h4> Autophagy plays a critical role in the survival and microbial clearance function of tissues that encounter the environment, such as airway epithelial cells ( AEC s). Contrary to the known roles of azithromycin ( AZM ) in promoting microbial clearance, our evidence shows that AZM is a potent inhibitor of autophagy ‒ an effect consistent with bacterial residency. Here we investigate the s...

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Literature Corpus work: cdfaf8aa-cdd3-5833-889d-ad37d9cc0455
DOI: 10.1101/2024.04.25.591217

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