Article

Integrated <i>in vivo</i> and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy

2026-03-16

Abstract excerpt

Oropouche virus (OROV) is an emerging arbovirus responsible for large outbreaks of febrile illness in Central and South America, with increasing reports of severe neurological disease and fatal outcomes. Despite its growing public health impact, no approved antiviral therapies or vaccines are currently available. Here, we show that favipiravir, a broad-spectrum nucleoside analogue, robustly suppresses OROV replica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e62af47e-0f2f-5b79-9498-36949e766809
DOI: 10.64898/2026.03.16.712021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated <i>in vivo</i> and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapyDOI 10.64898/2026.03.16.712021Read

MicroRNA and cellular targets profiling reveal miR-217 and miR-576-3p as proviral factors during Oropouche infectionSemantic proximity Read

Oropouche Virus Infection and Pathogenesis Are Restricted by MAVS, IRF-3, IRF-7, and Type I Interferon Signaling Pathways in Nonmyeloid CellsSemantic proximity Read

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika VirusesSemantic proximity Read

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent miceSemantic proximity Read

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice.Semantic proximity Read

Systematic transcriptomic analysis enables targeted drug repurposing for neurotropic flavivirus infectionsSemantic proximity Read

Emerging Infections of CNS : Avian Influenza A Virus, R ift V alley Fever Virus and Human ParechovirusSemantic proximity Read

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophagesSemantic proximity Read

Microcephaly-like phenotype triggered by novel reassortant and prototypic Oropouche Virus strains in brain organoidsSemantic proximity Read

Characterization of neural infection by Oropouche orthobunyavirusSemantic proximity Read

A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and PhlebovirusSemantic proximity Read

Small aberrant viral genomes induce the innate immune response to arenavirusesSemantic proximity Read