Article

Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signature

2021-11-11

Abstract excerpt

Precision medicine offers remarkable potential for the treatment of cancer, but is largely focused on tumors that harbor actionable mutations. Gene expression signatures can expand the scope of precision medicine by predicting response to traditional (cytotoxic) chemotherapy agents without relying on changes in mutational status. We present a novel signature extraction method, inspired by the principle of converge...

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Literature Corpus work: cd7240ff-3846-5785-bb29-40513ed679ed
DOI: 10.1101/2021.11.10.21265799

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