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Article

Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system.

Journal of pediatric surgery - 1 Mar 2010

Cheng Zhi, Dhall Deepti, Zhao Lifu, Wang Hanlin L, Doherty Terence M, Bresee Catherine, Frykman Philip K

Abstract excerpt

PURPOSE: The aim of the study was to characterize enterocolitis in the Ednrb-null (Ednrb-/-) mouse with aganglionosis of the colon and to develop and validate a semiquantitative histopathologic grading system to assess enterocolitis. METHODS: We isolated colon and ileal specimens of Ednrb-/- and control mice (Ednrb+/+) and performed histochemical staining (H&E) on tissue sections. After establishing inflammation...

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Identifiers

PMID: 20223308
DOI: 10.1016/j.jpedsurg.2009.06.009
PMCID: PMC4370315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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