Article

LYN Mutations in Breast Cancer: Association with Central Nervous System Metastasis and Domain-Level Insights

2025-10-20

Abstract excerpt

<title>Abstract</title> <p> Objectives: Central nervous system (CNS) metastasis is a major driver of morbidity in metastatic breast cancer, yet the molecular determinants of CNS tropism remain incompletely defined. <italic>LYN</italic> , a Src-family kinase integrating receptor tyrosine kinase and integrin signaling, is a biologically plausible mediator of metastatic traits. <h4>Design:</h4> We performed a ret...

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Literature Corpus work: cd27c2ac-af87-565d-a562-0b2dd5abc0e0
DOI: 10.21203/rs.3.rs-7597855/v1

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