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Article

Azacitidine and Sorafenib Therapy in a Pediatric Patient With Refractory Acute Myeloid Leukemia With Monosomy 7 and Somatic PTPN11 Mutation.

Pediatric blood & cancer - 1 Mar 2016

Dahl Nathan A, Michaels Samantha T, McMasters Richard L, Chandra Sharat, O'Brien Maureen M

Abstract excerpt

Monosomy 7 is a well-documented cytogenetic aberration in pediatric acute myeloid leukemia (AML) and may occur in combinations with molecular abnormalities including PTPN11 mutation. PTPN11 mutations contribute to leukemogenesis through upregulation of Ras pathway signaling. We present the case of a 3-year-old female with AML with monosomy 7 and somatic PTPN11 mutation who was refractory to conventional AML...

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Topics

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Share to Antimetabolites, Antineoplastic
Share to Azacitidine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to Niacinamide

Share to Phenylurea Compounds

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Share to Stem Cell Transplantation

Source

Identifiers

PMID: 26485542
DOI: 10.1002/pbc.25805

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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