Article

Hierarchical optimization of biochemical networks

2024-08-08

Abstract excerpt

Biological signalling systems are complex, and efforts to build mechanistic models must confront a huge parameter space, indirect and incomplete data, and frequently encounter multiscale and multiphysics phenomena. We present HOSS, a framework for Hierarchical Optimization of Systems Simulations, to address such problems. HOSS operates by breaking down extensive systems models into individual pathway blocks organi...

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Literature Corpus work: ccc2e3d1-59cf-5712-924a-129702a61684
DOI: 10.1101/2024.08.06.606818

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