Article

Benchmarking sketching methods on spatial transcriptomics data

2025-08-31

Abstract excerpt

High-throughput spatial transcriptomics (ST) now profiles hundreds of thousands of cells or locations per section, creating computational bottlenecks for routine analysis. Sketching, or intelligent sub-sampling, addresses scale by selecting small, representative subsets. While effective for scRNA-seq data, existing sketching methods, which optimize coverage in expression space but ignore physical location, can int...

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Literature Corpus work: cca619c2-2c14-505e-8b5c-40596ea43dcc
DOI: 10.1101/2025.08.26.672376

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