Article

Spaceland: Histology-Guided Reconstruction of High-Resolution Whole-Organ 3D Molecular Atlases from Sparse Spatial Transcriptomics

2026-07-27

Abstract excerpt

Reconstructing whole organs in three-dimensional molecular detail is a key step toward building virtual organs for modeling tissue organization, disease progression and drug perturbation responses. However, high-resolution whole-organ spatial transcriptomic profiling remains impractical, forcing a trade-off between reconstruction fidelity and sampling density. Here, we introduce Spaceland, a morphology-guided fram...

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Identifiers and source

Literature Corpus work: 15b41c94-e951-5808-a36a-6e5d9910e1e2
DOI: 10.64898/2026.07.23.739686

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