Article

<i>Clostridioides difficile</i>MreE (PBP2) variants facilitate clinical disease during cephalosporin exposures

2023-10-24

Abstract excerpt

Cephalosporins are the most common triggers of healthcare-associated Clostridioides difficile infections (CDI). Here, we confirm gene-level drivers of cephalosporin resistance and their roles in promoting disease. Genomic-epidemiologic analyses of 306 C. difficile isolates from a hospital surveillance program monitoring asymptomatic carriers and CDI patients identified prevalent third-generation cephalosporin resi...

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Literature Corpus work: cca29ae7-04c9-5ff3-b21c-cd601ff60aec
DOI: 10.1101/2023.10.23.23297415

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