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Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in ‘Epidemic’ Lineages of Multi Drug-Resistant <i>Clostridioides difficile</i>

2022-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Clostridioides difficile remains a key cause of healthcare-associated infection, with multi-drug-resistant (MDR) lineages causing high mortality (≥20%) outbreaks. Cephalosporin treatment is a long-established risk factor, and antimicrobial stewardship a key control. A mechanism underlying raised cephalosporin MICs has not been identified in C. difficile , but among other species resistance is o...

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Literature Corpus work
10608bc8-c869-5567-a591-3fbe240e255f
DOI
10.1101/2022.05.23.493179
Open publication

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Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in ‘Epidemic’ Lineages of Multi Drug-Resistant <i>Clostridioides difficile</i>DOI 10.1101/2022.05.23.493179
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