Article
Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage-tumor interaction axes among different lineages of pituitary neuroendocrine tumors.
Genome medicine - 24 Apr 2024
Lin Shaojian, Dai Yuting, Han Changxi, Han Tianyi, Zhao Linfeng, Wu Renyan, Liu Jianyue, Zhang Bo, Huang Ning, Liu Yanting, Lai Shujing, Shi Jintong, Wang Yu, Lou Meiqing, Xie Jing, Cheng Yijun, Tang Hao, Yao Hong, Fang Hai, Zhang Yan, Wu Xuefeng, Shen Lei, Ye Youqiong, Xue Li, Wu Zhe Bao
Abstract excerpt
BACKGROUND: Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, the precise immunological environment and its control over tumor cells are poorly understood. METHODS: The heterogeneity, spatial distribution, and clinical significance of macrophages in PitNETs were analyzed...
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