Article

Targeted Enzymatic Fragmentation of Lipoprotein(a) via Kringle IV Domains: A Clearance-Enhancing Therapeutic Strategy for Cardiovascular Disease

2025-09-30

Abstract excerpt

<h4>Background</h4> Elevated lipoprotein(a) [Lp(a)] is an independent, genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). Its unique apolipoprotein(a) [apo(a)] component contains variable Kringle IV (KIV) domain repeats that influence secretion, thrombosis, and atherogenesis. Current therapies antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) suppress hepati...

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Literature Corpus work: cc501aef-8ab6-5406-8278-4d289121eefb
DOI: 10.1101/2025.09.28.679088

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