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Gut microbiota metabolic pathways: Key players in knee osteoarthritis development.

Experimental gerontology - 15 Oct 2024

Di Jingkai, Xi Yujia, Wu Yawen, Di Yijing, Xing Xinglong, Zhang Zhibo, Xiang Chuan

Abstract excerpt

OBJECTIVE: To confirm the causality of gut microbiota pathway abundance and knee osteoarthritis (KOA). METHODS: Microbial metabolic pathways were taken as exposures, with data from the Dutch Microbiome Project (DMP). Data on KOA from the UK Biobank were utilized as endpoints. In addition, we extracted significant and independent single nucleotide polymorphisms as instrumental variables. Two-sample Mendelian...

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PMID: 39226947
DOI: 10.1016/j.exger.2024.112566

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