Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases.

Enzyme and microbial technology - 1 Oct 2022

Billot Raphaël, Plener Laure, Grizard Damien, Elias Mikael H, Chabrière Éric, Daudé David

Abstract excerpt

Quorum sensing (QS) is a molecular communication system used by microorganisms to adopt behaviors in a cell density-dependent manner. Lactonase enzymes, able to hydrolyze the signal molecules acyl-homoserine lactones (AHL) can counteract QS-mediated virulence in Gram-negative bacteria. Optimizing lactonases activity or specificity for AHL through enzyme engineering approaches is thus highly attractive to increase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyl-Butyrolactones
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pseudomonas aeruginosa

Share to Quorum Sensing

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 35797848
DOI: 10.1016/j.enzmictec.2022.110092
PMCID: PMC10310055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases.PMID 35797848Read ↗

Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing InhibitorsSemantic proximity Read ↗

Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264.Semantic proximity Read ↗

Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A reviewSemantic proximity Read ↗

Influence of quorum sensing in multiple phenotypes of the bacterial pathogen Chromobacterium violaceum.Semantic proximity Read ↗

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching LactonasesSemantic proximity Read ↗

Recent research advances on Chromobacterium violaceumSemantic proximity Read ↗

Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase.Semantic proximity Read ↗

Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens.Semantic proximity Read ↗

A Quorum-Quenching Approach To Investigate the Conservation of Quorum-Sensing-Regulated Functions within the Burkholderia cepacia ComplexSemantic proximity Read ↗

Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensingSemantic proximity Read ↗

Biodiversity of N-acyl homoserine lactonase (aiiA) gene from Bacillus subtilis.Semantic proximity Read ↗

Novel approaches for the design and discovery of quorum-sensing inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.