Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis for the substrate specificity of quorum signal synthases.

Proceedings of the National Academy of Sciences of the United States of America - 22 Aug 2017

Dong Shi-Hui, Frane Nicole D, Christensen Quin H, Greenberg E Peter, Nagarajan Rajesh, Nair Satish K

Abstract excerpt

In several Proteobacteria, LuxI-type enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier protein (ACP)-coupled fatty acids or CoA-aryl/acyl moieties as progenitors. Little is known about the molecular mechanism of signal biosynthesis, the basis for substrate specificity, or the rationale for donor specificity for any LuxI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligases

Share to Protein Conformation

Share to Proteobacteria

Share to Quorum Sensing

Share to S-Adenosylmethionine

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 28784791
DOI: 10.1073/pnas.1705400114
PMCID: PMC5576808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis for the substrate specificity of quorum signal synthases.PMID 28784791Read ↗

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching LactonasesSemantic proximity Read ↗

Structural Insight Into Aeromonas Hydrophila AHL Synthase AhyI Driving Acyl-ACP Selective RecognitionSemantic proximity Read ↗

Crystal Structure and Identification of Two Key Amino Acids Involved in AI-2 Production and Biofilm Formation in Streptococcus suis LuxSSemantic proximity Read ↗

Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.Semantic proximity Read ↗

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation.Semantic proximity Read ↗

Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity.Semantic proximity Read ↗

Analysis of the DNA-binding domain of the <i>Pseudomonas aeruginosa</i> quorum sensing transcription factor LasRSemantic proximity Read ↗

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.Semantic proximity Read ↗

Expanding the substrate selectivity of the fimsbactin biosynthetic adenylation domain, FbsHSemantic proximity Read ↗

Structural Comparison of Acinetobacter baumannii β-ketoacyl-acyl Carrier Protein Reductases in Fatty Acid and Aryl Polyene BiosynthesisSemantic proximity Read ↗

Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Discrimination between closely related cellular metabolites by the SAM-I riboswitch.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.