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Article

Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264.

Frontiers in cellular and infection microbiology - 1 Jan 2023

Gonzales Mélanie, Plener Laure, Armengaud Jean, Armstrong Nicholas, Chabrière Éric, Daudé David

Abstract excerpt

Introduction: Burkholderia thailandensis is a study model for Burkholderia pseudomallei, a highly virulent pathogen, known to be the causative agent of melioidosis and a potential bioterrorism agent. These two bacteria use an (acyl-homoserine lactone) AHL-mediated quorum sensing (QS) system to regulate different behaviors including biofilm formation, secondary metabolite productions, and motility. Methods: Using...

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PMID: 37333853
DOI: 10.3389/fcimb.2023.1190859
PMCID: PMC10272358

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