Article

Bayesian estimation of gene constraint from an evolutionary model with gene features

2023-06-13

Abstract excerpt

<title>Abstract</title> <p>Measures of selective constraint on genes have been used for many applications including clinical interpretation of rare coding variants, disease gene discovery, and studies of genome evolution. However, widely-used metrics are severely underpowered at detecting constraint for the shortest ∼25% of genes, potentially causing important pathogenic mutations to be overlooked. We developed a...

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Literature Corpus work: 0ce7b5aa-54f5-5464-8951-108643fa70c4
DOI: 10.21203/rs.3.rs-3012879/v1

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