Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

10 Jul 2023

Abstract excerpt

Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to wield them in the development of therapeutics and vaccines. During the COVID-19 pandemic, two mRNA vaccines were developed and approved in record-breaking time, revolutionizing the vaccine development landscape. Although first-generation COVID-19 mRNA vaccines have demonstrated over 90% efficacy, alongside strong immunogenicity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to RNA Interference and Gene Delivery
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37430088
DOI: 10.1038/s12276-023-00999-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccinesPMID 37430088Read ↗

Shared Clinical and Immunologic Features of mRNA Vaccines: Preliminary Results from a Comparative Clinical StudySemantic proximity Read ↗

From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine LandscapeSemantic proximity Read ↗

Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseasesSemantic proximity Read ↗

Current Developments and Challenges of mRNA VaccinesSemantic proximity Read ↗

mRNA Vaccine Technology Beyond COVID-19Semantic proximity Read ↗

mRNA Vaccines: A Prospective Analysis of Long-term, Multi-target, and Autoimmune DisordersSemantic proximity Read ↗

mRNA-Based Vaccine for COVID-19: They Are New but Not Unknown!Semantic proximity Read ↗

The dawn of mRNA vaccines: The COVID-19 caseSemantic proximity Read ↗

The Importance of RNA-Based Vaccines in the Fight against COVID-19: An OverviewSemantic proximity Read ↗

Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trialSemantic proximity Read ↗

Infectious disease mRNA vaccines and a review on epitope prediction for vaccine designSemantic proximity Read ↗

The Unique Features and Collateral Immune Effects of mRNA-Based COVID-19 Vaccines: Potential Plausible Causes of Adverse Events and ComplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.