Article
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Genome biology - 14 Sept 2017
Heinig Matthias, Adriaens Michiel E, Schafer Sebastian, van Deutekom Hanneke W M, Lodder Elisabeth M, Ware James S, Schneider Valentin, Felkin Leanne E, Creemers Esther E, Meder Benjamin, Katus Hugo A, Rühle Frank, Stoll Monika, Cambien François, Villard Eric, Charron Philippe, Varro Andras, Bishopric Nanette H, George Alfred L, Dos Remedios Cristobal, Moreno-Moral Aida, Pesce Francesco, Bauerfeind Anja, Rüschendorf Franz, Rintisch Carola, Petretto Enrico, Barton Paul J, Cook Stuart A, Pinto Yigal M, Bezzina Connie R, Hubner Norbert
Abstract excerpt
BACKGROUND: Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. RESULTS: Here we report the first in-depth survey of heart transcriptome variation using RNA-sequencing in 97 patients with dilated cardiomyopathy and 108 non-diseased controls. We reveal extensive differences of gene expression and...
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