Article

Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex

2025-04-28

Abstract excerpt

<h4>Summary</h4> During infections, vertebrates develop stereotypic symptoms such as elevated body temperature, reduced appetite, and lethargy. These changes, collectively known as sickness syndrome, are orchestrated by the brain in response to immune mediators released during systemic inflammation. While the roles of subcortical regions, including the hypothalamus and brainstem nuclei, in regulating sickness sym...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca327b73-f731-54e8-8934-53ac82a4e27c
DOI: 10.1101/2025.04.28.651028

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortexDOI 10.1101/2025.04.28.651028Read

Divergent Behavioral and Circuit-Level Adaptations to Acute and Chronic Gastric Electrical StimulationSemantic proximity Read

Spatially resolved cellular and circuit architecture of the insular cortex controlling different dimensions of painSemantic proximity Read

Machine Learning Guided Video Analysis Identifies Sound-Evoked Pain Behaviors from Facial Grimace and Body Cues in MiceSemantic proximity Read

LabGrymace: Automated Analysis of Mouse Grimace for Quantitative Assessment of Pain DynamicsSemantic proximity Read

Modeling behavior to disentangle motion-related effects in functional ultrasound imaging in awake, head-fixed miceSemantic proximity Read

Distinct Ca2+ signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity Read

Comprehensive profiling of anaesthetised brain dynamics across phylogenySemantic proximity Read

Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in miceSemantic proximity Read

The activity of deep cortical layers characterizes the complexity of brain responses during wakefulness following electrical stimulationSemantic proximity Read

Distinct Ca <sup>2+</sup> signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity Read

Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brainSemantic proximity Read

Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in miceSemantic proximity Read