Article

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

2024-12-17

Abstract excerpt

Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturing. Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies. Here, we developed humanized GLP1R mouse m...

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Literature Corpus work: 088c5cbd-3e2a-580a-af9c-e858c2fb19c0
DOI: 10.1101/2024.12.12.628169

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