Drug response profiling guides precision therapy in relapsed and refractory childhood acute lymphoblastic leukemia

Abstract excerpt

Children with relapsed or refractory acute lymphoblastic leukemia (ALL) require more effective and less toxic therapies. We established a prospective, multicenter Drug Response Profiling (DRP) registry ( NCT06550102 ) integrating functional testing into precision-guided treatment. DRP was performed for 340 patients from 17 European countries with a turn-around time of two-weeks. Image-based drug screening with ov...

Topics

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• Acute Lymphoblastic Leukemia research
• Acute Myeloid Leukemia Research
• Child
• Drug Resistance, Neoplasm
• Mutation
• Myeloproliferative Neoplasms: Diagnosis and Treatment
• Protein Degradation and Inhibitors
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

c9c50578-19b9-54b7-9441-c5e3102b25e1

DOI

10.64898/2026.04.08.26350164