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Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

1 Jul 2025

Abstract excerpt

Abstract Ex vivo drug response profiling is emerging as a valuable tool for identifying drug resistance mechanisms and advancing precision medicine in hematological cancers. However, the functional impact of dysregulation of the epigenome and transcriptome in this context remains poorly understood. In this study, we combined ex vivo drug sensitivity profiling with transcriptomic and epigenomic analyses in...

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PMID: 40727946
DOI: 10.1002/hem3.70176

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