Article

The generation of ROS by exposure to trihalomethanes promotes the IκBα/NF-kB/p65 complex dissociation in human lung fibroblast

2024-07-11

Abstract excerpt

Disinfection by-products to obtain drinking water, such as CH2Cl2, CHCl3, and BrCHCl2, elicit cytotoxicity and hyperproliferation in human lung fibroblasts (MRC-5). Enzymes of their biotransformation modulate these damages and can generate toxic metabolites. However, it is unknown that the response to oxidative stress is involved in cellular hyperproliferation modulated by nuclear factor-kappa B (NF-κB). Hen...

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Literature Corpus work: c9c1fa87-1ca7-56b4-9e9d-58799b2d2704
DOI: 10.20944/preprints202407.0790.v2

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