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Article

Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens.

JAMA network open - 5 Feb 2020

Parikh Kaushal, Huether Robert, White Kevin, Hoskinson Derick, Beaubier Nike, Dong Haidong, Adjei Alex A, Mansfield Aaron S

Abstract excerpt

Importance: Tumor mutation burden (TMB) is an emerging factor associated with survival with immunotherapy. When tumor-normal pairs are available, TMB is determined by calculating the difference between somatic and germline sequences. In the case of commonly used tumor-only sequencing, additional steps are needed to estimate the somatic alterations. Computational tools have been developed to determine germline...

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Identifiers

PMID: 32108894
DOI: 10.1001/jamanetworkopen.2020.0202
PMCID: PMC7049088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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