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Article

Bias and inconsistency in the estimation of tumour mutation burden.

BMC cancer - 2 Aug 2022

Makrooni Mohammad A, O'Sullivan Brian, Seoighe Cathal

Abstract excerpt

BACKGROUND: Tumour mutation burden (TMB), defined as the number of somatic mutations per megabase within the sequenced region in the tumour sample, has been used as a biomarker for predicting response to immune therapy. Several studies have been conducted to assess the utility of TMB for various cancer types; however, methods to measure TMB have not been adequately evaluated. In this study, we identified two...

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Identifiers

PMID: 35918650
DOI: 10.1186/s12885-022-09897-3
PMCID: PMC9347149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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