The impact of testosterone on paraventricular nucleus gene expression in male and female spontaneously hypertensive rats

Abstract excerpt

<h4>Background</h4> Hypertension is a polygenic, complex disease that impacts men and women differently; whilst the incidence of high blood pressure (BP) is roughly equal over a lifetime, men typically are at higher risk of developing the disease earlier in life, before 50 years of age. There is adequate evidence that the brain is critical for the BP setpoint. The paraventricular nucleus (PVN) of the hypothalamus...

Topics

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• Gene Expression
• Gene Expression Profiling
• Gene Expression Regulation
• Genome-Wide Association Study
• Organ Specificity
• Polymorphism, Single Nucleotide
• Sex Characteristics
• Testosterone

Identifiers and source

Literature Corpus work

c95f4eaa-aa6e-509d-acbe-466327e00ea8

DOI

10.1101/2025.02.20.639267